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Pääsivu > Tutkimusartikkelit - Article > Sneha K.S. Sheth, Yongling Li, Christopher A.Shaw. Is exposure to aluminum adjuvants associated with social impairments in mice? A pilot study. Journal of Inorganic Biochemistry. Available online 21 November 2017
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Sneha K.S. Sheth, Yongling Li, Christopher A.Shaw. Is exposure to aluminum adjuvants associated with social impairments in mice? A pilot study. Journal of Inorganic Biochemistry. Available online 21 November 2017

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Sneha K.S. Sheth, Yongling Li, Christopher A.Shaw. Is exposure to aluminum adjuvants associated with social impairments in mice? A pilot study. Journal of Inorganic Biochemistry. Available online 21 November 2017

  • Alumiinia käytetään useissa lasten rokotteissa adjuvanttina, vaikka se tiedetään neurotoksiseksi aineeksi.
  • Tutkimuksessa pyrittiin selvittämään alumiiniadjuvanttien vaikutuksia hiirten sosiaaliseen käytökseen
  • Vastasyntyneinä alumiinihydroksidiruiskeen saaneilla hiirillä havaittiin tutkimuksessa poikkeavaa sosiaalista käytöstä.

Abstract

Background

Our group has shown that significant correlations exist between rates of Autism Spectrum Disorder (ASD) and total aluminum adjuvants given to children through vaccines in several Western countries. These correlations satisfied eight out of nine Hill criteria for causality. Experimental studies have demonstrated a range of behavioral abnormalities in young mice after postnatal exposure to aluminum. To build on our previous work, the current study will investigate the effect of aluminum adjuvants on social behaviour in mice. Anomalies in social interaction are a key characteristic of those with ASD.

Methods

Neonatal CD-1 mice pups were injected with either a total of 550 μg of aluminum hydroxide gel (experimental group) or saline (control) spread out during the first two weeks of postnatal life. The mice were then subjected to behavioral tests for social interest and social novelty at postnatal week 8, 17 and 29. p-Values were calculated using the Mann-Whitney and Kruskal Wallis tests.

Results

Aluminum injected mice showed diminished social interest compared to controls at week 8 (p = 0.016) and 17 (p = 0.012). They also demonstrated abnormal social novelty from controls at week 8 (p = 0.002) and week 29 (p = 0.042).

Conclusion

This is the first experimental study, to our knowledge, to demonstrate that aluminum adjuvants can impair social behaviour if applied in the early period of postnatal development. The study, however, is insufficient to make any assertive claims about the link between aluminum adjuvants and ASD in humans.